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This updated and expanded new edition of a successful book describes genetic diagnostic entities of neuromuscular disorders. Neuromuscular syndromes are presented clinically either as a case study or as an overview from the literature, accompanied by text presenting molecular defects, and differential diagnosis.
This collection of neuromuscular disorders features the differential clinical phenotypes related to each genotype and are representative of the whole spectrum of a genetic muscle disorder, helping the clinician and neuromuscular physician to make a diagnosis. Key points for each genetic disease are identified to suggest treatment, when available, or the main clinical exams useful in follow-up of patients.
Genetic Neuromuscular Disorders: A Case-Based Approach is aimed at neuromuscular physicians and neurology residents.
The increase in average life expectancy observed over recent decades has brought new challenges to nephrology practice. Several renal diseases are more frequent in elderly patients today, and even in healthy older individuals renal physiology has its own peculiarities. This leads to the need for a specific approach on renal aging and renal function in the elderly. However, despite the relevance of this topic, there are few books exclusively dedicated to geriatric nephrology.
This book fills this gap by presenting a comprehensive overview of the differences between normal renal aging and chronic renal disease in the aged, and describes the particular aspects of nephropathy in the elderly, addressing it in a practical and clinically applicable fashion.
Clinical Nephrogeriatrics bridges the gap between nephrology and geriatrics, discussing the most important issues concerning the relationship between these two medical specialties. This evidence-based resource, written by prominent specialists with extensive clinical experience, offers nephrologists, geriatricians, family physicians, and other medical professionals valuable practical guidelines and insights to enhance their clinical practice and provide optimal care.
This book focuses on the critical care of the patient with acute, acute on chronic and chronic liver failure as well as the peri-operative care of the patient with liver transplantation. Each of these disease processes is unique in pathophysiological manifestations, underpinnings of physiology and treatment options.
Patients with acute, chronic or acute on chronic liver failure are a growing fraction of ICU admissions. Hepatic Critical Care serves as the essential reference for both practicing intensivists at community hospitals and tertiary referral centers. This textbook is also targeted towards trainees specifically interested in taking care of patients with liver disease and liver transplantation.
This comprehensive book examines the complex interplay between endocrine and kidney disorders, and how this inter-relationship impacts patients with chronic kidney disease. Authored by experts in areas of endocrinology and nephrology, chapters cover a variety of topics, including diabetes, metabolic syndrome, thyroid dysfunction, gonadal disorders, dyslipidemia, mineral bone disorders, obesity, and pituitary disorders. These comorbidities are thoroughly examined and provide the clinician, researcher, and trainee with a greater understanding of the impact of endocrine disorders on kidney disease patients, the ability to identify persistent gaps in knowledge for future investigation, and move closer towards the goal of improving the health and survival of the chronic kidney disease population.
This book deals with the essential factors in the personalization of treatment for primary breast cancer. These include host issues, lymph node surgery, radiation therapy, and preoperative systemic treatment requiring specialized knowledge, multidisciplinary care experience, techniques, and research. Locoregional treatment in conjunction with systemic treatments is another important factor, with options for local therapy significantly affected by genetic BRCA mutation. Axillary treatment issues have become top priorities in recent primary breast cancer care, and these are highlighted in the book’s presentation of technological advances in lymph node mapping and diagnosis, axillary clearance in patients with nodal metastasis, and the role of axillary surgery. Attention is also given to locoregional treatment after preoperative systemic therapy. Because therapeutic impact differs depending upon biological characteristics such as tumor subtype, local therapy should be based both on tumor biology and on therapeutic response in parallel. Associated translational research and mathematical prediction tools such as nomograms also are introduced. This book provides the essence of primary breast cancer care, particularly its individualization with novel therapeutic concepts and strategies, and will greatly benefit physicians and clinical investigators in breast cancer institutions.
This book provides an up-to-date review of the risk factors and genetics influencing the development of this rare disease. This volume presents clinical features and recent advances in histopathology and molecular profiling are analyzed, providing a valuable aid to clinicians in tailoring treatment to both the patient and the tumour. Readers will find important insights into the most effective strategies for making or negating a diagnosis of MBC. Within this timely volume, consideration is also given to the psychological needs of men with breast cancer alongside a discussion of the most effective support methods. The surgical management of the disease is examined, together with algorithms for local and systemic therapy. Owing to the problem of late diagnosis in MBC, many men have advanced or disseminated disease at diagnosis and, as such, the evidence-based management of these cases is reviewed. Male Breast Cancer concludes with a discussion on determining prognosis and the likely future developments in MBC with a focus on improved diagnosis and survival. Male Breast Cancer will be of interest to breast surgeons, oncologists, breast radiologists, breast histopathologists and breast care nurses worldwide.
This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.
This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer with the aim of providing the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy. The role of the hormonal therapies abiraterone and enzalutamide and docetaxel-based chemotherapy in castration-resistant prostate cancer and hormone-sensitive metastatic disease is carefully evaluated. Among the other therapies discussed are LHRH agonists and antagonists, cabazitaxel, radium-223, and various novel agents still under clinical trials. The section on surgical approaches addresses, among other topics, the use of robot-assisted radical prostatectomy, pelvic lymphadenectomy, and the benefits of adjuvant and neoadjuvant therapy. The current role of external beam radiotherapy, alone or in combination with ADT and brachytherapy, for locally advanced disease is reviewed. Management of Advanced Prostate Cancer will be a valuable resource for practitioners at all levels of expertise
This book provides a comprehensive and up-to-date overview of current polypectomy techniques and describes new perspectives in the field. A wide variety of topics are covered, including classification of colon polyps, established polypectomy techniques and related controversies, advanced endoscopic resection, endoscopic submucosal dissection, the use of submucosal injection solutions, management of complications, management of anticoagulant and antiplatelet medications, and post-polypectomy endoscopic surveillance. Information is also provided on a novel risk calculation score for adenoma recurrence after polypectomy, developed by the editors of the book and their colleagues. In acquainting readers with the state of the art in the field, Colon Polypectomy will serve as a valuable reference and practical tool for all who perform the procedure, which is of ever-increasing importance given the recent success of colon cancer screening campaigns in leading to earlier detection of colon polyps.
Educational advancement in the field of psoriatic arthritis which this book will provide is consistent with GRAPPA’s aims and objectives leading to a productive synergy. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), is recognized world wide as the leading international society for the study and promotion of awareness of psoriatic arthritis. GRAPPA is an association of leading rheumatologists, dermatologists, representatives of patient service leagues and other stakeholders focused on psoriasis and PsA.Psoriatic Arthritis (PsA) ranks with rheumatoid arthritis and axial spondyloarthritis as one of the most prevalent inflammatory arthropathies worldwide. There is now a significant global awareness among Rheumatologists, Dermatologists, Internal Medicine Specialists, Gastroenterologists, General Practitioners, Family Practitioners, Physiotherapists, Nurse Specialists, Immunogenetics and many other Health Care Professionals with regards to the importance of psoriatic arthritis.
This book provides a much-needed, internationally oriented text, focusing on specific aspects of heart disease in women. Despite the large amount of information available, there is still considerable confusion regarding female patients. As such, the book highlights the health events that occur during aging in women and that may influence the future CVD risk. For instance, pregnancy-related disorders are important predictors for CVD risk in women, and inflammatory diseases like rheumatic, thyroid disorders etc, which also interfere with CVD risk, are also more common in women. Adopting a multidisciplinary approach, including gynecology and endocrinology, it offers separate chapters on female-specific manifestations of ischemic heart disease, such as Tako Tsubo CMP and spontaneous coronary artery dissections. The book also discusses the effects and side effects of important medications. The chapters are clearly formatted, making it easy for readers to find subjects of interest.
In dit leerboek worden op heldere en indringende wijze de anatomie van het geboortekanaal, de mechanismen van de normale baring en de uitvoering van obstetrische interventies, zoals kunstverlossingen en keizersneden in het ziekenhuis, weergegeven. Maar ook problemen die in de eerste lijn kunnen voorkomen, bijvoorbeeld schouderdystocie, worden uitvoerig behandeld.
‘Obstetrische interventies’ is bedoeld voor studenten verloskunde en geneeskunde, artsen (in opleiding), tropenartsen, (klinisch) verloskundigen en gynaecologen.
Met de bijdragen van ruim dertig auteurs uit Nederland, Vlaanderen en de Verenigde Staten wordt in dit boek inzicht gegeven in de keuzes die artsen en verloskundigen vóór, tijdens en na bevallingen elke dag en nacht weer moeten maken. De keuzes zijn zo veel mogelijk evidence-based.
This volume provides a comprehensive, state-of-the art review of inflammatory bowel disease and its management through the use of telemedicine applications. The book reviews barriers to successful outcomes in patients with IBD and offers a rationale for how self-management and telemedicine approaches can improve care in chronic illnesses such as IBD. This volume also includes a summary of the burden of telephone encounters in patients with IBD, characteristics of frequent callers to the office, outcomes associated with high telephone use, and strategies to provide education via telephone to patients with IBD. Prior literature on implementation of teleconsultation in research and clinical practice, as well as mobile applications used to track symptoms, quality of life, diet, and medication use in IBD are also explored in the book.
Written by experts in the field, Telemanagement of Inflammatory Bowel Disease is a valuable resource for gastroenterologists, surgeons, and other clinicians dealing with, and interested in, this novel adjunct to routine care for inflammatory bowel disease.
The main target of clinical and academic cardiology activities is to optimize the patient’s management and ultimately their welfare. Professionals manage patients according to their own understanding of disease process; clinicians concentrate on alleviating the symptoms and echocardiographers on identifying the disease. This book helps to ‘cross the barrier’ and describes the common ground between physiologic disturbances and their management which should ideally form the shared basis for understanding and managing all cardiac problems.
A practical review of the many uses of echocardiography in clinical practice, Clinical Echocardiography is designed to integrate and refine the investigation of cardiac disorders within the framework of the pathologic, physiologic and surgical appearances of heart disease. It has been common to consider echocardiographic findings separately from the more physical aspects of heart disease. However, with the development of new imaging modalities such as three- and four-dimensional echocardiography, it has become necessary to consider this imaging as a window on the heart. This book aids the cardiologist, cardiac surgeon and echocardiographer to integrate their knowledge within the overall management of cardiac disease in a clinically relevant manner.
The latest edition of this text provides a comprehensive overview of the “natural flow of knowledge” regarding inflammatory bowel disease, with an emphasis on state-of-the art approaches that should be the basis for diagnosis and treatment of most patients. In addition to updated chapters, this volume includes new chapters on such topics as the impending biosimilar revolution, quality of care, and new challenges to previously held beliefs about IBD diagnosis, treatment, and pathogenesis. The book is also one of the first to have a chapter written specifically by and for physician extenders in the training of colleagues and the treatment of patients, which is of increasing importance moving forward in the medical profession.
Written by experts in the field, Inflammatory Bowel Disease: Diagnosis and Therapeutics, Third Edition is a valuable resource for physicians, nurses, researchers, and other health care providers interested in the latest cutting-edge knowledge for treating patients with inflammatory bowel disease.
Management of Prostate Cancer
A Multidisciplinary Apporach
Editors: Bolla, Michel, van Poppel, Hendrik (Eds.)
2nd ed. 2017, VIII, 422 p. 76 illus., 64 illus. in color.
This book, now in an extensively revised second edition, provides an exhaustive review of the state of the art in the management of prostate cancer, from screening to treatment, with emphasis on a multidisciplinary approach. The editors are very excited about the outstanding new or updated contributions from the different expert authors.
The opening chapters address basic aspects including epidemiology, pathology, biology, genetics, and chemoprevention. The role of individual and mass screening is carefully appraised, and extensive attention is devoted to diagnosis and clinical work-up by means of recently implemented investigations such as multiparametric MRI and choline PET-CT.
The use of active surveillance is examined in detail. Subsequent chapters discuss the different therapies that may be employed: open and minimally invasive, including robot-assisted, radical prostatectomy, the various forms of radiation treatment, high-intensity focused ultrasound, cryotherapy, hormonal manipulations, chemotherapy, targeted therapies, and immunotherapy. Up-to-date results from practice-changing phase III randomized clinical trials are included and special insights are provided into the interpretation of results and the patient’s perspective.
Urology at a Glance is a concise, practical guide to diagnostic and therapeutic decision making. The book is divided into two parts. The first focuses on the pathway from symptom to diagnosis and covers the full range of symptoms commonly encountered by the urologist. Any particular symptom can be located within a matter of seconds and in each case differential diagnosis is explained with the aid of a flow chart. The second part of the book is devoted to the pathway from diagnosis to therapy, with each short chapter devoted to a specific diagnosis. Basic information is provided on the disease in question, along with an outline of state of the art treatment options and possible complications. Again, flow charts are used to help the reader to reach the correct therapeutic decision in different circumstances. Numerous high-definition photographs and illustrations are also included. This book will be a great asset for urologists and practitioners in related disciplines
This text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation strategies, in depth analysis of combination and sequencing strategies, outlines upcoming novel drugs and trends in research, and stresses the role of palliative care in this incurable disease. Managing Metastatic Prostate Cancer in Your Urological Oncology Practice will serve as a very useful resource for physicians and researchers dealing with, and interested in prostate cancer. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and will include the most up to date scientific and clinical information.
Psoriatic Arthritis and Psoriasis
Pathology and Clinical Aspects
Editors: Adebajo, A., Boehncke, W.-H., Gladman, D.D., Mease, P.J. (Eds.)
2016, 316 p. with illus. in color.
Educational advancement in the field of psoriatic arthritis which this book will provide is consistent with GRAPPA’s aims and objectives leading to a productive synergy. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), is recognized world wide as the leading international society for the study and promotion of awareness of psoriatic arthritis. GRAPPA is an association of leading rheumatologists, dermatologists, representatives of patient service leagues and other stakeholders focused on psoriasis and PsA.Psoriatic Arthritis (PsA) ranks with rheumatoid arthritis and axial spondyloarthritis as one of the most prevalent inflammatory arthropathies worldwide.
There is now a significant global awareness among Rheumatologists, Dermatologists, Internal Medicine Specialists, Gastroenterologists, General Practitioners, Family Practitioners, Physiotherapists, Nurse Specialists, Immunogenetics and many other Health Care Professionals with regards to the importance of psoriatic arthritis.
Radiological Features and Clinical-Surgical Correlations
Editors: Lo Re, Giuseppe, Midiri, Massimo (Eds.)
1st ed. 2016, X, 177 p. 45 illus., 26 illus. in color.
This book describes and illustrates the radiological findings that are characteristic of Crohn’s disease and correlates these appearances with clinical and surgical findings in order to assist the reader in implementing an appropriate diagnostic approach in this complex disease, which often differs from patient to patient. All of the modern imaging modalities and techniques are covered, including ultrasound, multidetector row computed tomography (MDCT), magnetic resonance imaging (MRI), and combinations of MDCT and MRI with enteroclysis and enterography. The current value of X-ray and the role of endoscopy are also examined. Care is taken to cover specific patient groups, including pediatric patients, those with perianal disease or anal fistulas, and patients who have undergone surgery. In addition to surgical approaches, including minimally invasive options, other new therapies are discussed. The book will be invaluable for diagnostic radiologists, gastroenterologists, and surgeons.
Practical Pediatric Dermatology
Controversies in Diagnosis and Treatment
Editors: Oranje, Arnold P., Al-Mutairi, Nawaf, Shwayder, Tor (Eds.)
1st ed. 2016, XII, 269 p. 47 illus., 44 illus. in color.
This book presents a selection of controversial issues of practical importance in pediatric dermatology with the aim of enabling the reader to adopt a well-balanced and evidence-based approach to the management of dermatological disorders encountered during childhood. It is not, therefore, structured according to a basic disease classification; rather it addresses a series of dilemmas in the diagnosis and treatment of a wide range of conditions, including inflammatory disorders, tumors, immune and autoimmune disorders. In addition to areas of debate in the management of individual conditions, controversies in the use of particular types of treatment, for example retinoids, cyclosporin, acyclovir, and laser therapy, are considered and relevant psychological aspects are discussed. Practical Pediatric Dermatology will assist pediatricians and dermatologists in decision making during daily clinical practice.
The Right Ventricle in Health and Disease
Series: Respiratory Medicine
Editors: Voelkel, Norbert F., Schranz, Dietmar (Eds.)
2015, XVII, 488 p. 149 illus., 94 illus. in color.
The Right Ventricle in Health and Disease provides a comprehensive and up-to-date database and collection of the available information which describes the structure and function of the normal right ventricle. The right ventricular performance and function reserve has now finally moved to the center of the stage as clinicians recognize that the drugs presently used to treat patients with severe pulmonary hypertension do not necessarily improve the performance of the right ventricle and because the survival depends on the right ventricular function that treatment strategies need to be developed to primarily protect the right ventricle from failing. In-depth chapters discuss right heart function and failure in patients with congenital heart diseases, review modern imaging techniques used to describe right ventricular form and function in patients with right heart failure (including cardiac MRI and PET scanning), describe ventricular interdependence: the left ventricle in pulmonary hypertension and discuss the concept of the sick lung circulation and its contribution to right heart failure. Treatment strategies of chronic right heart failure including drugs and mechanical devices are also discussed.
This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care.
Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in depth review of proven therapeutic options, including bone targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigations are also reviewed. The text provides up to date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence based medicine.
As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.
Because of the increasing burden of hepatitis C and fatty liver disease, there is an explosion in the prevalence of chronic liver failure and hence its complications. The onset of Hepatic Encephalopathy (HE) in these patients has a significant impact on the quality of life, morbidity and mortality. Unfortunately, the approach observed by most clinicians to this complex disorder is minimalistic.
Hepatic Encephalopathy provides a comprehensive review on pathophysiology and clinically important aspects in HE. Topics in basic physiology, nitrogen metabolism, new insights into pathogenesis and brain edema are covered in great detail. The authors have made a special effort by simplifying the complex aspects of pathogenesis and diagnosis so that it can be easily understood and applied clinically. This volume also focuses on recent developments regarding diagnoses of subtle forms of HE, also known as minimal or covert HE as well as on new treatments. Hepatic Encephalopathy will be of great value to gastroenterologists, hepatologists, pathologists, medical residents, fellows, internists, and general practitioners who treat patients with hepatic encephalopathy.
In dit boek staat informatie over de ziekte psoriasis en over bijbehorende onderzoeken, behandelingen en leefstijladviezen. Het boek is een verzameling van veelgestelde vragen uit de praktijk. De vragen zijn zo goed mogelijk beantwoord door de dermatologen Dr. David Njoo, Dr. Deepak Balak en Prof. dr. Peter van de Kerkhof en sluiten aan bij de nieuwste ontwikkelingen op het gebied van psoriasis.
Heb je een vraag die er niet tussen staat, dan kun je ook kijken op de websites van Psoriasispatiënten Nederland en van de Nederlandse Vereniging voor Dermatologie en Venereologie. Of stel de vraag aan je eigen dermatoloog.